Bioinformatics Analyst I - Sun Lab

Summary

The University of Rochester is committed to advancing the values of equity, leadership, and integrity. They are seeking a Bioinformatics Analyst I to contribute to computational analysis and develop bioinformatic pipelines for various genomic studies, particularly in cancer research.

Responsibilities

• Contributes to computational analysis of data generated across multiple research projects in the Sun lab, with a focus on cancer evolution, tumor immunology, transposable element biology, and multi-omics data integration
• Develops, maintains, and applies bioinformatic pipelines for bulk and single cells RNA sequencing, spatial transcriptomics , epigenetic profiling, epigenomic profiling, proteomics, and genomic analysis
• Perform data processing, quality control, statistical modeling, machine learning, and integrative analysis to identify biologically meaningful patterns and generate testable hypotheses
• Collaborate closely with experimental researcher to design studies, interpret results, and support manuscript and grant preparation
• Contributes to the development of reproducible computational workflows, data visualization tools, and laboratory data-management infrastructure while helping establish and expand the laboratory’s computational research capabilities
• Responsible for the preparation, maintenance, curation, and analysis of data from high-throughput sequencing (HTS) projects and other projects that generate and complement genomic data
• Contributes to the design and interpretation of experimental projects and results
• Prepares data and reports for discussion, use and interpretation by investigators
• Performs computational analysis include but not limited to statistical test, machine learning, and mathematical modeling
• Prepares reports, presents findings in both oral presentation and paper writing
• Provides standard bioinformatics analyses, such as unsupervised clustering, differential expression, and data visualization, as well as applying more sophisticated algorithms for inference of cell state, gene regulatory networks, and cell-cell interactions
• Completes maintenance of computational pipelines, data management, and sharing, consulting with researchers on analytical methods and carrying out custom bioinformatics projects
• Other duties as assigned

Skills

• Bachelor's degree required
• 1 year of relevant experience required or equivalent combination of education and experience required
• Experience with genomics and bioinformatics in a clinical laboratory including setting up, testing and maintaining bioinformatics workflows required
• Demonstrated ability to achieve results in a deadline driven environment with multiple priorities and multiple stakeholders required
• Ability to learn and deliver work to audience with varied backgrounds required
• Experience/proficiency with python/java/C++/R, bash scripting, statistical programming using R or related tools, web-development, pipeline development, and database query SRA downloading and ability to prototype software solutions for data analysis and use of next generation sequencing tools such as STAR(solo), TopHat, DeSeq, BWA, GATK, minimap2 and others required
• Master degree preferred

Qualifications

Must Haves

• Bachelor's degree required
• 1 year of relevant experience required or equivalent combination of education and experience required
• Experience with genomics and bioinformatics in a clinical laboratory including setting up, testing and maintaining bioinformatics workflows required
• Demonstrated ability to achieve results in a deadline driven environment with multiple priorities and multiple stakeholders required
• Ability to learn and deliver work to audience with varied backgrounds required
• Experience/proficiency with python/java/C++/R, bash scripting, statistical programming using R or related tools, web-development, pipeline development, and database query SRA downloading and ability to prototype software solutions for data analysis and use of next generation sequencing tools such as STAR(solo), TopHat, DeSeq, BWA, GATK, minimap2 and others required

Nice to Haves

• Master degree preferred